Determination of ifenprodil by LC–MS/MS and its application to a pharmacokinetic study in healthy Chinese volunteers

Determination of ifenprodil by LC–MS/MS and its application to a pharmacokinetic study in healthy Chinese volunteers

This paper reports the development and validation of an assay for ifenprodil based on liquid chromatography–tandem mass spectrometry (LC–MS/MS) and its application to a pharmacokinetic study involving single and multiple intravenous infusions to healthy Chinese volunteers. After sample preparation o...

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Bibliographic Details
Main Authors: Jing Yang, Chengtao Lu, Wei Song, Jiankang Li, Yi Ding, Yanrong Zhu, Jinyi Cao, Likun Ding, Yanyan Jia, Aidong Wen
Format: Article
Language:English
Published: Elsevier 2013-05-01
Series:Acta Pharmaceutica Sinica B
Subjects:
Ifenprodil
Liquid/liquid extraction
LC–MS/MS
Pharmacokinetics
Intravenous infusion
Human
Plasma
Online Access:http://www.sciencedirect.com/science/article/pii/S2211383513000336

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http://www.sciencedirect.com/science/article/pii/S2211383513000336

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