Cytokine inflammatory threat, but not LPS one, shortens GABAergic synaptic currents in the mouse spinal cord organotypic cultures

Cytokine inflammatory threat, but not LPS one, shortens GABAergic synaptic currents in the mouse spinal cord organotypic cultures

Abstract Background Synaptic dysfunction, named synaptopathy, due to inflammatory status of the central nervous system (CNS) is a recognized factor potentially underlying both motor and cognitive dysfunctions in neurodegenerative diseases. To gain knowledge on the mechanistic interplay between local...

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Bibliographic Details
Main Authors: Vincenzo Giacco, Giulia Panattoni, Manuela Medelin, Elena Bonechi, Alessandra Aldinucci, Clara Ballerini, Laura Ballerini
Format: Article
Language:English
Published: BMC 2019-06-01
Series:Journal of Neuroinflammation
Subjects:
Organotypic spinal slices
Patch-clamp
Synaptic currents
Neuroinflammation
GABAergic inhibition
GABAergic receptors
Online Access:http://link.springer.com/article/10.1186/s12974-019-1519-z

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http://link.springer.com/article/10.1186/s12974-019-1519-z

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