Steroidal antibiotics are antimetabolites of Acanthamoeba steroidogenesis with phylogenetic implications

Steroidal antibiotics are antimetabolites of Acanthamoeba steroidogenesis with phylogenetic implications

Pathogenic organisms may be sensitive to inhibitors of sterol biosynthesis, which carry antimetabolite properties, through manipulation of the key enzyme, sterol methyltransferase (SMT). Here, we isolated natural suicide substrates of the ergosterol biosynthesis pathway, cholesta-5,7,22,24-tetraenol...

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Bibliographic Details
Main Authors: Wenxu Zhou, Emilio Ramos, Xunlu Zhu, Paxtyn M. Fisher, Medhanie E. Kidane, Boden H. Vanderloop, Crista D. Thomas, Juqiang Yan, Ujjal Singha, Minu Chaudhuri, Michael T. Nagel, W.David Nes
Format: Article
Language:English
Published: Elsevier 2019-05-01
Series:Journal of Lipid Research
Subjects:
anti-amoeba drugs
suicide substrate
sterol biosynthesis
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520322689

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http://www.sciencedirect.com/science/article/pii/S0022227520322689

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