On the Estimation of Heritability with Family-Based and Population-Based Samples

On the Estimation of Heritability with Family-Based and Population-Based Samples

For a family-based sample, the phenotypic variance-covariance matrix can be parameterized to include the variance of a polygenic effect that has then been estimated using a variance component analysis. However, with the advent of large-scale genomic data, the genetic relationship matrix (GRM) can be...

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Bibliographic Details
Main Authors: Youngdoe Kim, Young Lee, Sungyoung Lee, Nam Hee Kim, Jeongmin Lim, Young Jin Kim, Ji Hee Oh, Haesook Min, Meehee Lee, Hyeon-Jeong Seo, So-Hyun Lee, Joohon Sung, Nam H. Cho, Bong-Jo Kim, Bok-Ghee Han, Robert C. Elston, Sungho Won, Juyoung Lee
Format: Article
Language:English
Published: Hindawi Limited 2015-01-01
Series:BioMed Research International
Online Access:http://dx.doi.org/10.1155/2015/671349

Internet

http://dx.doi.org/10.1155/2015/671349

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