Oxalomalate reduces expression and secretion of vascular endothelial growth factor in the retinal pigment epithelium and inhibits angiogenesis: Implications for age-related macular degeneration

Oxalomalate reduces expression and secretion of vascular endothelial growth factor in the retinal pigment epithelium and inhibits angiogenesis: Implications for age-related macular degeneration

Clinical and experimental observations indicate a critical role for vascular endothelial growth factor (VEGF), secreted by the retinal pigment epithelium (RPE), in pathological angiogenesis and the development of choroidal neovascularization (CNV) in age-related macular degeneration (AMD). RPE-media...

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Bibliographic Details
Main Authors: Sung Hwan Kim, Hyunjin Kim, Hyeong Jun Ku, Jung Hyun Park, Hanvit Cha, Seoyoon Lee, Jin Hyup Lee, Jeen-Woo Park
Format: Article
Language:English
Published: Elsevier 2016-12-01
Series:Redox Biology
Subjects:
VEGF
Retinal pigment epithelium
Oxalomalate
Reactive oxygen species
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231716301082

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http://www.sciencedirect.com/science/article/pii/S2213231716301082

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