Human decellularized bone scaffolds from aged donors show improved osteoinductive capacity compared to young donor bone.

Human decellularized bone scaffolds from aged donors show improved osteoinductive capacity compared to young donor bone.

To improve the safe use of allograft bone, decellularization techniques may be utilized to produce acellular scaffolds. Such scaffolds should retain their innate biological and biomechanical capacity and support mesenchymal stem cell (MSC) osteogenic differentiation. However, as allograft bone is de...

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Bibliographic Details
Main Authors: Christopher A Smith, Tim N Board, Paul Rooney, Mark J Eagle, Stephen M Richardson, Judith A Hoyland
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2017-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC5432108?pdf=render

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http://europepmc.org/articles/PMC5432108?pdf=render

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