Low transformation growth factor-β1 production and collagen synthesis correlate with the lack of hepatic periportal fibrosis development in undernourished mice infected with Schistosoma mansoni

Low transformation growth factor-β1 production and collagen synthesis correlate with the lack of hepatic periportal fibrosis development in undernourished mice infected with Schistosoma mansoni

Undernourished mice infected (UI) submitted to low and long-lasting infections by Schistosoma mansoni are unable to develop the hepatic periportal fibrosis that is equivalent to Symmers’ fibrosis in humans. In this report, the effects of the host’s nutritional status on parasite (worm load, egg viab...

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Bibliographic Details
Main Authors: Andreia Ferreira Barros, Sheilla Andrade Oliveira, Camila Lima Carvalho, Fabiana Leticia Silva, Veruska Cintia Alexandrino de Souza, Anekecia Lauro da Silva, Roni Evencio de Araujo, Bruno Solano F Souza, Milena Botelho Pereira Soares, Vlaudia MA Costa, Eridan de Medeiros Coutinho
Format: Article
Language:English
Published: Instituto Oswaldo Cruz, Ministério da Saúde 2014-04-01
Series:Memórias do Instituto Oswaldo Cruz.
Subjects:
Schistosomiasis mansoni
undernutrition
liver fibrosis
cytokines
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762014000200210&lng=en&tlng=en

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