Testicular degeneration in Huntington disease

Testicular degeneration in Huntington disease

Huntington disease (HD) is an adult onset, neurodegenerative disorder that results from CAG expansion in the HD gene. Recent work has demonstrated testicular degeneration in mouse models of HD and alterations in the hypothalamic–pituitary–gonadal (HPG) axis in HD patients. Here, we show that HD pati...

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Bibliographic Details
Main Authors: Jeremy M. Van Raamsdonk, Zoe Murphy, David M. Selva, Reza Hamidizadeh, Jacqueline Pearson, Ǻsa Petersén, Maria Björkqvist, Cameron Muir, Ian R. Mackenzie, Geoffrey L. Hammond, A. Wayne Vogl, Michael R. Hayden, Blair R. Leavitt
Format: Article
Language:English
Published: Elsevier 2007-06-01
Series:Neurobiology of Disease
Subjects:
Huntington disease
Huntingtin
Testis
Hypothalamic–pituitary–gonadal axis
Testosterone
YAC128 mouse model
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996107000228

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http://www.sciencedirect.com/science/article/pii/S0969996107000228

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