Minute-scale persistence of a GPCR conformation state triggered by non-cognate G protein interactions primes signaling

Minute-scale persistence of a GPCR conformation state triggered by non-cognate G protein interactions primes signaling

Recent reports suggest the spatial and temporal coupling of receptor-effector interactions, with the potential to diversify downstream responses. Here authors demonstrate the temporal coupling of cognate and non-cognate G protein interactions through priming of GPCR conformation.

Bibliographic Details
Main Authors: Tejas M. Gupte, Michael Ritt, Matthew Dysthe, Rabia U. Malik, Sivaraj Sivaramakrishnan
Format: Article
Language:English
Published: Nature Publishing Group 2019-10-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-019-12755-9

Internet

https://doi.org/10.1038/s41467-019-12755-9

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