The novel fusion proteins, GnRH-p53 and GnRHIII-p53, expression and their anti-tumor effect.

p53, one of the most well studied tumor suppressor factor, is responsible to a variety of damage owing to the induction of apoptosis and cell cycle arrest in the tumor cells. More than 50% of human tumors contain mutation or deletion of p53. Gonadotrophin-releasing hormone (GnRH), as the ligand of G...

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Bibliographic Details
Main Authors: Peiyuan Jia, Yu Zhao, Shaoping Wu, Junhua Wu, Shan Gao, Ying Tong, Yuxia Wang
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3817058?pdf=render