Obatoclax, a BH3 Mimetic, Enhances Cisplatin-Induced Apoptosis and Decreases the Clonogenicity of Muscle Invasive Bladder Cancer Cells via Mechanisms That Involve the Inhibition of Pro-Survival Molecules as Well as Cell Cycle Regulators

Obatoclax, a BH3 Mimetic, Enhances Cisplatin-Induced Apoptosis and Decreases the Clonogenicity of Muscle Invasive Bladder Cancer Cells via Mechanisms That Involve the Inhibition of Pro-Survival Molecules as Well as Cell Cycle Regulators

Several studies by our group and others have determined that expression levels of Bcl-2 and/or Bcl-xL, pro-survival molecules which are associated with chemoresistance, are elevated in patients with muscle invasive bladder cancer (MI-BC). The goal of this study was to determine whether combining Oba...

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Bibliographic Details
Main Authors: Thomas M. Steele, George C. Talbott, Anhao Sam, Clifford G. Tepper, Paramita M. Ghosh, Ruth L. Vinall
Format: Article
Language:English
Published: MDPI AG 2019-03-01
Series:International Journal of Molecular Sciences
Subjects:
bladder cancer
BH3 mimetics
Obatoclax
cisplatin
apoptosis
Online Access:http://www.mdpi.com/1422-0067/20/6/1285

Internet

http://www.mdpi.com/1422-0067/20/6/1285

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