αVβ3 Integrin regulates astrocyte reactivity

αVβ3 Integrin regulates astrocyte reactivity

Abstract Background Neuroinflammation involves cytokine release, astrocyte reactivity and migration. Neuronal Thy-1 promotes DITNC1 astrocyte migration by engaging αVβ3 Integrin and Syndecan-4. Primary astrocytes express low levels of these receptors and are unresponsive to Thy-1; thus, inflammation...

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Bibliographic Details
Main Authors: Raúl Lagos-Cabré, Alvaro Alvarez, Milene Kong, Francesca Burgos-Bravo, Areli Cárdenas, Edgardo Rojas-Mancilla, Ramón Pérez-Nuñez, Rodrigo Herrera-Molina, Fabiola Rojas, Pascal Schneider, Mario Herrera-Marschitz, Andrew F. G. Quest, Brigitte van Zundert, Lisette Leyton
Format: Article
Language:English
Published: BMC 2017-09-01
Series:Journal of Neuroinflammation
Subjects:
Integrins
Inflammation
Reactive astrocytes
Amyotrophic lateral sclerosis
Cell migration
Online Access:http://link.springer.com/article/10.1186/s12974-017-0968-5

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http://link.springer.com/article/10.1186/s12974-017-0968-5

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