Selective dicer suppression in the kidney alters GSK3β/β-catenin pathways promoting a glomerulocystic disease.

Selective dicer suppression in the kidney alters GSK3β/β-catenin pathways promoting a glomerulocystic disease.

Dicer is a crucial enzyme for the maturation of miRNAs. Mutations in the Dicer gene are highly associated with Pleuro Pulmonary Blastoma-Family Dysplasia Syndrome (PPB-FDS, OMIM 601200), recently proposed to be renamed Dicer syndrome. Aside from the pulmonary phenotype (blastoma), renal nephroma and...

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Bibliographic Details
Main Authors: Anna Iervolino, Francesco Trepiccione, Federica Petrillo, Manuela Spagnuolo, Marzia Scarfò, Daniela Frezzetti, Gabriella De Vita, Mario De Felice, Giovambattista Capasso
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4370407?pdf=render

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http://europepmc.org/articles/PMC4370407?pdf=render

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