Hyperglycemia-induced Renal P2X7 Receptor Activation Enhances Diabetes-related Injury

Hyperglycemia-induced Renal P2X7 Receptor Activation Enhances Diabetes-related Injury

Diabetes is a leading cause of renal disease. Glomerular mesangial expansion and fibrosis are hallmarks of diabetic nephropathy and this is thought to be promoted by infiltration of circulating macrophages. Monocyte chemoattractant protein-1 (MCP-1) has been shown to attract macrophages in kidney di...

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Bibliographic Details
Main Authors: Robert I. Menzies, John W.R. Booth, John J. Mullins, Matthew A. Bailey, Frederick W.K. Tam, Jill T. Norman, Robert J. Unwin
Format: Article
Language:English
Published: Elsevier 2017-05-01
Series:EBioMedicine
Subjects:
Glucose
Purine
P2
Renal
Cytokine
CKD
Online Access:http://www.sciencedirect.com/science/article/pii/S235239641730155X

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http://www.sciencedirect.com/science/article/pii/S235239641730155X

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