Mdivi-1, a mitochondrial fission inhibitor, modulates T helper cells and suppresses the development of experimental autoimmune encephalomyelitis

Mdivi-1, a mitochondrial fission inhibitor, modulates T helper cells and suppresses the development of experimental autoimmune encephalomyelitis

Abstract Background Unrestrained activation of Th1 and Th17 cells is associated with the pathogenesis of multiple sclerosis and its animal model, experimental autoimmune encephalomyelitis (EAE). While inactivation of dynamin-related protein 1 (Drp1), a GTPase that regulates mitochondrial fission, ca...

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Bibliographic Details
Main Authors: Yan-Hua Li, Fang Xu, Rodolfo Thome, Min-Fang Guo, Man-Luan Sun, Guo-Bin Song, Rui-lan Li, Zhi Chai, Bogoljub Ciric, A. M. Rostami, Mark Curtis, Cun-Gen Ma, Guang-Xian Zhang
Format: Article
Language:English
Published: BMC 2019-07-01
Series:Journal of Neuroinflammation
Subjects:
Experimental autoimmune encephalomyelitis
Dynamin-related protein 1
Mdivi-1
T cells
Online Access:http://link.springer.com/article/10.1186/s12974-019-1542-0

Internet

http://link.springer.com/article/10.1186/s12974-019-1542-0

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