Knocking down metabotropic glutamate receptor 1 improves survival and disease progression in the SOD1G93A mouse model of amyotrophic lateral sclerosis

Knocking down metabotropic glutamate receptor 1 improves survival and disease progression in the SOD1G93A mouse model of amyotrophic lateral sclerosis

Amyotrophic lateral sclerosis (ALS) is a late-onset fatal neurodegenerative disease reflecting degeneration of upper and lower motoneurons (MNs). The cause of ALS and the mechanisms of neuronal death are still largely obscure, thus impairing the establishment of efficacious therapies. Glutamate (Glu...

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Bibliographic Details
Main Authors: Marco Milanese, Francesco Giribaldi, Marcello Melone, Tiziana Bonifacino, Ilaria Musante, Enrico Carminati, Pia I.A. Rossi, Laura Vergani, Adriana Voci, Fiorenzo Conti, Aldamaria Puliti, Giambattista Bonanno
Format: Article
Language:English
Published: Elsevier 2014-04-01
Series:Neurobiology of Disease
Subjects:
Amyotrophic lateral sclerosis
SOD1G93A mouse
Metabotropic glutamate type 1 receptor
Metabotropic glutamate type 5 receptor
Metabotropic glutamate type 1 receptor knocking down
Glutamate transmission
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996113003185

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http://www.sciencedirect.com/science/article/pii/S0969996113003185

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