Evidence for 2-Methoxyestradiol-Mediated Inhibition of Receptor Tyrosine Kinase RON in the Management of Prostate Cancer

Evidence for 2-Methoxyestradiol-Mediated Inhibition of Receptor Tyrosine Kinase RON in the Management of Prostate Cancer

2-Methoxyestradiol (2-ME<sub>2</sub>) possesses anti-tumorigenic activities in multiple tumor models with acceptable tolerability profile in humans. Incomplete understanding of the mechanism has hindered its development as an anti-tumorigenic compound. We have identified for the first-ti...

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Bibliographic Details
Main Authors: Izhar Singh Batth, Shih-Bo Huang, Michelle Villarreal, Jingjing Gong, Divya Chakravarthy, Brian Keppler, Sridharan Jayamohan, Pawel Osmulski, Jianping Xie, Paul Rivas, Roble Bedolla, Michael A. Liss, I-Tien Yeh, Robert Reddick, Hiroshi Miyamoto, Rita Ghosh, Addanki P Kumar
Format: Article
Language:English
Published: MDPI AG 2021-02-01
Series:International Journal of Molecular Sciences
Subjects:
castration-resistant prostate cancer
receptor tyrosine kinase
RON
atomic force microscopy
2-methoxyestradiol
epithelial mesenchymal transition
Online Access:https://www.mdpi.com/1422-0067/22/4/1852

Internet

https://www.mdpi.com/1422-0067/22/4/1852

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