A Comparison Between Denaturing Gradient Gel Electrophoresis and Denaturing High Performance Liquid Chromatography in Detecting Mutations in Genes Associated with Hereditary Non-Polyposis Colorectal Cancer (HNPCC) and the Identification of 9 New Mutations Previously Unidentified by DGGE

A Comparison Between Denaturing Gradient Gel Electrophoresis and Denaturing High Performance Liquid Chromatography in Detecting Mutations in Genes Associated with Hereditary Non-Polyposis Colorectal Cancer (HNPCC) and the Identification of 9 New Mutations Previously Unidentified by DGGE

<p>Abstract</p> <p>Denaturing high performance liquid chromatography is a relatively new method by which heteroduplex structures formed during the PCR amplification of heterozygote samples can be rapidly identified. The use of this technology for mutation detection in hereditary no...

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Bibliographic Details
Main Authors: Meldrum Cliff J, McPhillips Mary, Crooks Renee, Thomas Lesley, Edkins Ted, Creegan Rohanna, Miller Ewan, Agrez Michael, Scott Rodney J
Format: Article
Language:English
Published: BMC 2003-12-01
Series:Hereditary Cancer in Clinical Practice
Subjects:
DGGE
DHPLC
hereditary non-polyposis colorectal cancer mutation detection
Online Access:http://www.hccpjournal.com/content/1/1/39

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http://www.hccpjournal.com/content/1/1/39

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