Immunogenicity and Immune Silence in Human Cancer

Immunogenicity and Immune Silence in Human Cancer

Despite recent advances in cancer immunotherapy, the process of immunoediting early in tumorigenesis remains obscure. Here, we employ a mathematical model that utilizes the Cancer Genome Atlas (TCGA) data to elucidate the contribution of individual mutations and HLA alleles to the immunoediting proc...

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Bibliographic Details
Main Authors: Mark Yarmarkovich, Alvin Farrel, Artemio Sison, Moreno di Marco, Pichai Raman, Joshua L. Parris, Dimitrios Monos, Hongzhe Lee, Stefan Stevanovic, John M. Maris
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-03-01
Series:Frontiers in Immunology
Subjects:
immunoediting
immune evasion
neoantigens
HLA
cancer susceptibility
KRAS
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.00069/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2020.00069/full

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