Nanocarriers for DNA Vaccines: Co-Delivery of TLR-9 and NLR-2 Ligands Leads to Synergistic Enhancement of Proinflammatory Cytokine Release

Nanocarriers for DNA Vaccines: Co-Delivery of TLR-9 and NLR-2 Ligands Leads to Synergistic Enhancement of Proinflammatory Cytokine Release

Adjuvants enhance immunogenicity of vaccines through either targeted antigen delivery or stimulation of immune receptors. Three cationic nanoparticle formulations were evaluated for their potential as carriers for a DNA vaccine, and muramyl dipeptide (MDP) as immunostimulatory agent, to induce and i...

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Bibliographic Details
Main Authors: Johanna Poecheim, Simon Heuking, Livia Brunner, Christophe Barnier-Quer, Nicolas Collin, Gerrit Borchard
Format: Article
Language:English
Published: MDPI AG 2015-12-01
Series:Nanomaterials
Subjects:
adjuvants
toll-like receptor
NOD-like receptor
cationic nanoparticles
DNA vaccine
muramyl dipeptide
Online Access:http://www.mdpi.com/2079-4991/5/4/2317

Internet

http://www.mdpi.com/2079-4991/5/4/2317

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