Mitochondrial peptide BRAWNIN is essential for vertebrate respiratory complex III assembly

Small open reading frame-encoded peptides (SEPs), shorter than 100 amino acids, are involved in many cell biological processes. Here the authors identify 16 nuclear-encoded mitochondrial SEPs, including BRAWNIN, an essential regulator of respiratory chain complex III assembly and ATP production.

Bibliographic Details
Main Authors:	Shan Zhang, Boris Reljić, Chao Liang, Baptiste Kerouanton, Joel Celio Francisco, Jih Hou Peh, Camille Mary, Narendra Suhas Jagannathan, Volodimir Olexiouk, Claire Tang, Gio Fidelito, Srikanth Nama, Ruey-Kuang Cheng, Caroline Lei Wee, Loo Chien Wang, Paula Duek Roggli, Prabha Sampath, Lydie Lane, Enrico Petretto, Radoslaw M. Sobota, Suresh Jesuthasan, Lisa Tucker-Kellogg, Bruno Reversade, Gerben Menschaert, Lei Sun, David A. Stroud, Lena Ho
Format:	Article
Language:	English
Published:	Nature Publishing Group 2020-03-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-020-14999-2

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spelling	doaj-0910631e426f49c8a20e80729e44b71d2021-05-11T08:03:44ZengNature Publishing GroupNature Communications2041-17232020-03-0111111610.1038/s41467-020-14999-2Mitochondrial peptide BRAWNIN is essential for vertebrate respiratory complex III assemblyShan Zhang0Boris Reljić1Chao Liang2Baptiste Kerouanton3Joel Celio Francisco4Jih Hou Peh5Camille Mary6Narendra Suhas Jagannathan7Volodimir Olexiouk8Claire Tang9Gio Fidelito10Srikanth Nama11Ruey-Kuang Cheng12Caroline Lei Wee13Loo Chien Wang14Paula Duek Roggli15Prabha Sampath16Lydie Lane17Enrico Petretto18Radoslaw M. Sobota19Suresh Jesuthasan20Lisa Tucker-Kellogg21Bruno Reversade22Gerben Menschaert23Lei Sun24David A. Stroud25Lena Ho26Cardiovascular Metabolic Disorders Program, Duke-NUS Medical SchoolDepartment of Biochemistry and Molecular Biology, The Bio21 Molecular Science & Biotechnology Institute, University of MelbourneCardiovascular Metabolic Disorders Program, Duke-NUS Medical SchoolCardiovascular Metabolic Disorders Program, Duke-NUS Medical SchoolCancer and Stem Cell Biology Program, Duke-NUS Medical SchoolCardiovascular Metabolic Disorders Program, Duke-NUS Medical SchoolSIB-Swiss Institute of Bioinformatics and Department of Microbiology and Molecular Medicine, Faculty of Medicine, Geneva UniversityCentre for Computational Biology, Duke-NUS Graduate Medical School SingaporeBiobix, Lab of Bioinformatics and Computational Genomics, Department of Mathematical Modelling, Statistics and Bioinformatics, Ghent UniversityCardiovascular Metabolic Disorders Program, Duke-NUS Medical SchoolCardiovascular Metabolic Disorders Program, Duke-NUS Medical SchoolInstitute of Medical Biology, ASTARLee Kong Chian School of Medicine, Nanyang Technological UniversityInstitute of Molecular and Cell Biology, ASTARInstitute of Molecular and Cell Biology, ASTARSIB-Swiss Institute of BioinformaticsSkin Research Institute of Singapore, ASTARSIB-Swiss Institute of Bioinformatics and Department of Microbiology and Molecular Medicine, Faculty of Medicine, Geneva UniversityCentre for Computational Biology, Duke-NUS Graduate Medical School SingaporeInstitute of Molecular and Cell Biology, ASTARLee Kong Chian School of Medicine, Nanyang Technological UniversityCancer and Stem Cell Biology Program, Duke-NUS Medical SchoolInstitute of Medical Biology, ASTARBiobix, Lab of Bioinformatics and Computational Genomics, Department of Mathematical Modelling, Statistics and Bioinformatics, Ghent UniversityCardiovascular Metabolic Disorders Program, Duke-NUS Medical SchoolDepartment of Biochemistry and Molecular Biology, The Bio21 Molecular Science & Biotechnology Institute, University of MelbourneCardiovascular Metabolic Disorders Program, Duke-NUS Medical SchoolSmall open reading frame-encoded peptides (SEPs), shorter than 100 amino acids, are involved in many cell biological processes. Here the authors identify 16 nuclear-encoded mitochondrial SEPs, including BRAWNIN, an essential regulator of respiratory chain complex III assembly and ATP production.https://doi.org/10.1038/s41467-020-14999-2
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Shan Zhang Boris Reljić Chao Liang Baptiste Kerouanton Joel Celio Francisco Jih Hou Peh Camille Mary Narendra Suhas Jagannathan Volodimir Olexiouk Claire Tang Gio Fidelito Srikanth Nama Ruey-Kuang Cheng Caroline Lei Wee Loo Chien Wang Paula Duek Roggli Prabha Sampath Lydie Lane Enrico Petretto Radoslaw M. Sobota Suresh Jesuthasan Lisa Tucker-Kellogg Bruno Reversade Gerben Menschaert Lei Sun David A. Stroud Lena Ho
spellingShingle	Shan Zhang Boris Reljić Chao Liang Baptiste Kerouanton Joel Celio Francisco Jih Hou Peh Camille Mary Narendra Suhas Jagannathan Volodimir Olexiouk Claire Tang Gio Fidelito Srikanth Nama Ruey-Kuang Cheng Caroline Lei Wee Loo Chien Wang Paula Duek Roggli Prabha Sampath Lydie Lane Enrico Petretto Radoslaw M. Sobota Suresh Jesuthasan Lisa Tucker-Kellogg Bruno Reversade Gerben Menschaert Lei Sun David A. Stroud Lena Ho Mitochondrial peptide BRAWNIN is essential for vertebrate respiratory complex III assembly Nature Communications
author_facet	Shan Zhang Boris Reljić Chao Liang Baptiste Kerouanton Joel Celio Francisco Jih Hou Peh Camille Mary Narendra Suhas Jagannathan Volodimir Olexiouk Claire Tang Gio Fidelito Srikanth Nama Ruey-Kuang Cheng Caroline Lei Wee Loo Chien Wang Paula Duek Roggli Prabha Sampath Lydie Lane Enrico Petretto Radoslaw M. Sobota Suresh Jesuthasan Lisa Tucker-Kellogg Bruno Reversade Gerben Menschaert Lei Sun David A. Stroud Lena Ho
author_sort	Shan Zhang
title	Mitochondrial peptide BRAWNIN is essential for vertebrate respiratory complex III assembly
title_short	Mitochondrial peptide BRAWNIN is essential for vertebrate respiratory complex III assembly
title_full	Mitochondrial peptide BRAWNIN is essential for vertebrate respiratory complex III assembly
title_fullStr	Mitochondrial peptide BRAWNIN is essential for vertebrate respiratory complex III assembly
title_full_unstemmed	Mitochondrial peptide BRAWNIN is essential for vertebrate respiratory complex III assembly
title_sort	mitochondrial peptide brawnin is essential for vertebrate respiratory complex iii assembly
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2020-03-01
description	Small open reading frame-encoded peptides (SEPs), shorter than 100 amino acids, are involved in many cell biological processes. Here the authors identify 16 nuclear-encoded mitochondrial SEPs, including BRAWNIN, an essential regulator of respiratory chain complex III assembly and ATP production.
url	https://doi.org/10.1038/s41467-020-14999-2
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Mitochondrial peptide BRAWNIN is essential for vertebrate respiratory complex III assembly

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