Relationship between Delta Rhythm, Seizure Occurrence and Allopregnanolone Hippocampal Levels in Epileptic Rats Exposed to the Rebound Effect

Abrupt withdrawal from antiepileptic drugs is followed by increased occurrence of epileptic seizures, a phenomenon known as the “rebound effect”. By stopping treatment with levetiracetam (LEV 300 mg/kg/day, <i>n</i> = 15; vs saline, <i>n</i> = 15), we investigated the rebound...

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Bibliographic Details
Main Authors: Anna-Maria Costa, Chiara Lucchi, Asiye Malkoç, Cecilia Rustichelli, Giuseppe Biagini
Format: Article
Language:English
Published: MDPI AG 2021-02-01
Series:Pharmaceuticals
Subjects:
Online Access:https://www.mdpi.com/1424-8247/14/2/127