Inhibition of miRNA-212/132 improves the reprogramming of fibroblasts into induced pluripotent stem cells by de-repressing important epigenetic remodelling factors

Inhibition of miRNA-212/132 improves the reprogramming of fibroblasts into induced pluripotent stem cells by de-repressing important epigenetic remodelling factors

MicroRNAs (miRNAs) repeatedly have been demonstrated to play important roles in the generation of induced pluripotent stem cells (iPSCs). To further elucidate the molecular mechanisms underlying transcription factor-mediated reprogramming we have established a model, which allows for the efficient s...

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Bibliographic Details
Main Authors: Nils Pfaff, Steffi Liebhaber, Selina Möbus, Abbas Beh-Pajooh, Jan Fiedler, Angelika Pfanne, Axel Schambach, Thomas Thum, Tobias Cantz, Thomas Moritz
Format: Article
Language:English
Published: Elsevier 2017-04-01
Series:Stem Cell Research
Subjects:
Cellular reprogramming
Induced pluripotent stem cells
MicroRNAs
Epigenetic remodelling
Online Access:http://www.sciencedirect.com/science/article/pii/S1873506117300417

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http://www.sciencedirect.com/science/article/pii/S1873506117300417

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