Type 2 NADH Dehydrogenase Is the Only Point of Entry for Electrons into the Streptococcus agalactiae Respiratory Chain and Is a Potential Drug Target

Type 2 NADH Dehydrogenase Is the Only Point of Entry for Electrons into the Streptococcus agalactiae Respiratory Chain and Is a Potential Drug Target

The opportunistic pathogen Streptococcus agalactiae is the major cause of meningitis and sepsis in a newborn’s first week, as well as a considerable cause of pneumonia, urinary tract infections, and sepsis in immunocompromised adults. This pathogen respires aerobically if heme and quinone are availa...

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Bibliographic Details
Main Authors: Andrea M. Lencina, Thierry Franza, Matthew J. Sullivan, Glen C. Ulett, Deepak S. Ipe, Philippe Gaudu, Robert B. Gennis, Lici A. Schurig-Briccio
Format: Article
Language:English
Published: American Society for Microbiology 2018-07-01
Series:mBio
Subjects:
bacterial pathogenesis
electron transport chain
NADH dehydrogenase
Streptococcus agalactiae
drug discovery
Online Access:https://doi.org/10.1128/mBio.01034-18

Internet

https://doi.org/10.1128/mBio.01034-18

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