Structures of C-mannosylated anti-adhesives bound to the type 1 fimbrial FimH adhesin

Structures of C-mannosylated anti-adhesives bound to the type 1 fimbrial FimH adhesin

Selective inhibitors of the type 1 fimbrial adhesin FimH are recognized as attractive alternatives for antibiotic therapies and prophylaxes against Escherichia coli infections such as urinary-tract infections. To construct these inhibitors, the α-d-mannopyranoside of high-mannose N-glycans, recogniz...

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Bibliographic Details
Main Authors: Jerome de Ruyck, Marc F. Lensink, Julie Bouckaert
Format: Article
Language:English
Published: International Union of Crystallography 2016-05-01
Series:IUCrJ
Subjects:
bacterial adhesion
anti-adhesives
C-mannosides
FimH
variable immunoglobulin fold
protein structure
X-ray crystallography
intermolecular interactions
hydrogen bonding
Online Access:http://scripts.iucr.org/cgi-bin/paper?S2052252516002487

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http://scripts.iucr.org/cgi-bin/paper?S2052252516002487

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