In Vitro Metabolism of Donepezil in Liver Microsomes Using Non-Targeted Metabolomics

In Vitro Metabolism of Donepezil in Liver Microsomes Using Non-Targeted Metabolomics

Donepezil is a reversible acetylcholinesterase inhibitor that is currently the most commonly prescribed drug for the treatment of Alzheimer’s disease. In general, donepezil is known as a safe and well-tolerated drug, and it was not associated with liver abnormalities in several clinical trials. Howe...

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Bibliographic Details
Main Authors: Sin-Eun Kim, Hyung-Ju Seo, Yeojin Jeong, Gyung-Min Lee, Seung-Bae Ji, So-Young Park, Zhexue Wu, Sangkyu Lee, Sunghwan Kim, Kwang-Hyeon Liu
Format: Article
Language:English
Published: MDPI AG 2021-06-01
Series:Pharmaceutics
Subjects:
donepezil
metabolism
metabolomics
molecular networking
multivariate analysis
Online Access:https://www.mdpi.com/1999-4923/13/7/936

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https://www.mdpi.com/1999-4923/13/7/936

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