Generation of knockout rabbits using transcription activator-like effector nucleases

Generation of knockout rabbits using transcription activator-like effector nucleases

Zinc-finger nucleases and transcription activator-like effector nucleases are novel gene-editing platforms contributing to redefine the boundaries of modern biological research. They are composed of a non-specific cleavage domain and a tailor made DNA-binding module, which enables a broad range of g...

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Bibliographic Details
Main Authors: Yu Wang, Nana Fan, Jun Song, Juan Zhong, Xiaogang Guo, Weihua Tian, Quanjun Zhang, Fenggong Cui, Li Li, Philip N Newsome, Jon Frampton, Miguel A Esteban, Liangxue Lai
Format: Article
Language:English
Published: SpringerOpen 2014-01-01
Series:Cell Regeneration
Subjects:
Rabbits
Animal models
Zinc-finger nucleases
Transcription activator-like effector nucleases
TALENs
Genome editing
Knockout
Online Access:http://www.sciencedirect.com/science/article/pii/S2045976917300172

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http://www.sciencedirect.com/science/article/pii/S2045976917300172

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