17β-Estradiol Treatment Attenuates Neurogenesis Damage and Improves Behavior Performance After Ketamine Exposure in Neonatal Rats

17β-Estradiol Treatment Attenuates Neurogenesis Damage and Improves Behavior Performance After Ketamine Exposure in Neonatal Rats

Ketamine exposure disturbed normal neurogenesis in the developing brain and resulted in subsequent neurocognitive deficits. 17β-estradiol provides robust neuroprotection in a variety of brain injury models in animals of both sexes and attenuates neurodegeneration induced by anesthesia agents. In the...

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Bibliographic Details
Main Authors: Weisong Li, Huixian Li, Haidong Wei, Yang Lu, Shan Lei, Juan Zheng, Haixia Lu, Xinlin Chen, Yong Liu, Pengbo Zhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-06-01
Series:Frontiers in Cellular Neuroscience
Subjects:
neural stem cells
ketamine
neurotoxicity
17β-estradiol
p-GSK-3β
Online Access:https://www.frontiersin.org/article/10.3389/fncel.2019.00251/full

Internet

https://www.frontiersin.org/article/10.3389/fncel.2019.00251/full

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