A Collection of Single-Domain Antibodies that Crowd Ricin Toxin’s Active Site

A Collection of Single-Domain Antibodies that Crowd Ricin Toxin’s Active Site

In this report, we used hydrogen exchange-mass spectrometry (HX-MS) to identify the epitopes recognized by 21 single-domain camelid antibodies (V<sub>H</sub>Hs) directed against the ribosome-inactivating subunit (RTA) of ricin toxin, a biothreat agent of concern to military and public he...

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Bibliographic Details
Main Authors: Siva Krishna Angalakurthi, David J. Vance, Yinghui Rong, Chi My Thi Nguyen, Michael J. Rudolph, David Volkin, C. Russell Middaugh, David D. Weis, Nicholas J. Mantis
Format: Article
Language:English
Published: MDPI AG 2018-12-01
Series:Antibodies
Subjects:
toxin
antibody
camelid
vaccine
biodefense
hydrogen exchange-mass spectrometry
Online Access:https://www.mdpi.com/2073-4468/7/4/45

Internet

https://www.mdpi.com/2073-4468/7/4/45

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