Self-reactive T cells induce and perpetuate chronic relapsing arthritis

Self-reactive T cells induce and perpetuate chronic relapsing arthritis

Abstract Background CD4+ T cells play a central role during the early stages of rheumatoid arthritis (RA), but to which extent they are required for the perpetuation of the disease is still not fully understood. The aim of the current study was to obtain conclusive evidence that T cells drive chroni...

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Bibliographic Details
Main Authors: Jonatan Tuncel, Jens Holmberg, Sabrina Haag, Malin Hultqvist Hopkins, Lena Wester-Rosenlöf, Stefan Carlsen, Peter Olofsson, Rikard Holmdahl
Format: Article
Language:English
Published: BMC 2020-04-01
Series:Arthritis Research & Therapy
Subjects:
Chronic arthritis
Adoptive T cell transfer
PIA
Pristane
MHC class II
T cell depletion
Online Access:http://link.springer.com/article/10.1186/s13075-020-2104-7

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http://link.springer.com/article/10.1186/s13075-020-2104-7

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