Unexpected diversity of CRISPR unveils some evolutionary patterns of repeated sequences in Mycobacterium tuberculosis

Abstract Background Diversity of the CRISPR locus of Mycobacterium tuberculosis complex has been studied since 1997 for molecular epidemiology purposes. By targeting solely the 43 spacers present in the two first sequenced genomes (H37Rv and BCG), it gave a biased idea of CRISPR diversity and ignore...

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Bibliographic Details
Main Authors: Guislaine Refrégier, Christophe Sola, Christophe Guyeux
Format: Article
Language:English
Published: BMC 2020-11-01
Series:BMC Genomics
Online Access:https://doi.org/10.1186/s12864-020-07178-6