Roles of Mitochondrial DNA Mutations in Stem Cell Ageing

Roles of Mitochondrial DNA Mutations in Stem Cell Ageing

Mitochondrial DNA (mtDNA) mutations accumulate in somatic stem cells during ageing and cause mitochondrial dysfunction. In this review, we summarize the studies that link mtDNA mutations to stem cell ageing. We discuss the age-related behaviours of the somatic mtDNA mutations in stem cell population...

Full description

Bibliographic Details
Main Authors: Tianhong Su, Doug M. Turnbull, Laura C. Greaves
Format: Article
Language:English
Published: MDPI AG 2018-03-01
Series:Genes
Subjects:
stem cell
mitochondrial DNA mutation
ageing
purifying selection
mitochondrial mutagenesis
progenitor
mitochondrial disease
ageing mouse model
mitochondrial DNA-mutator mouse
mitochondria
Online Access:http://www.mdpi.com/2073-4425/9/4/182

Internet

http://www.mdpi.com/2073-4425/9/4/182

Similar Items