Intracolonic Mustard Oil Induces Visceral Pain in Mice by TRPA1-Dependent and -Independent Mechanisms: Role of Tissue Injury and P2X Receptors

Intracolonic Mustard Oil Induces Visceral Pain in Mice by TRPA1-Dependent and -Independent Mechanisms: Role of Tissue Injury and P2X Receptors

Both TRPA1 and purinergic P2X receptors have been proposed as potential targets for the treatment of visceral pain. We found that the intracolonic administration of a low dose mustard oil (0.5%), a well-known TRPA1 agonist, produced nociceptive responses and abdominal wall referred mechanical hypera...

Full description

Bibliographic Details
Main Authors: Rafael Gonzalez-Cano, Ángeles Montilla-García, Gloria Perazzoli, Jesús M. Torres, Francisco J. Cañizares, Eduardo Fernández-Segura, Michael Costigan, José M. Baeyens, Enrique J. Cobos
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-01-01
Series:Frontiers in Pharmacology
Subjects:
mustard oil
visceral pain
resiniferatoxin
TRPA1
TRPV1
P2X
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2020.613068/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2020.613068/full

Similar Items