Effects of 5-azacytidine on natural killer cell activating receptor expression in patients with refractory anemia with excess of blasts

Effects of 5-azacytidine on natural killer cell activating receptor expression in patients with refractory anemia with excess of blasts

Epigenetic drugs modify DNA methylation and are used in refractory anemia with excess of blasts (RAEB). These drugs may reactivate anti-oncogene expression and restore a normal phenotype instead of inducing antitumor toxicity, although they also have immunosuppressive effects on T-lymphocytes [1] In...

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Bibliographic Details
Main Authors: Régis T. Costello, Amélie Leclercq, Thérèse Le Treut, Carole Sanchez, Delphine Mercier, Gérard Sébahoun
Format: Article
Language:English
Published: Elsevier 2015-01-01
Series:Leukemia Research Reports
Subjects:
Natural killer cells
Refractory anemia with excess of blasts
Natural cytotoxicity receptors
Demethylation
5-azacytidine
Online Access:http://www.sciencedirect.com/science/article/pii/S2213048915000023

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http://www.sciencedirect.com/science/article/pii/S2213048915000023

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