Understanding How Wnt Influences Destruction Complex Activity and β-Catenin Dynamics

Summary: Despite extensive research on the canonical Wnt signaling pathway, the mechanism by which this signal downregulates the activity of destruction complexes and inhibits β-catenin degradation remains controversial. In particular, recent attention has focused on two main competing mechanisms—in...

Full description

Bibliographic Details
Main Authors: Abhirup Mukherjee, Neha Dhar, Mark Stathos, David V. Schaffer, Ravi S. Kane
Format: Article
Language:English
Published: Elsevier 2018-08-01
Series:iScience
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004218300956