Resveratrol and arsenic trioxide act synergistically to kill tumor cells in vitro and in vivo.

BACKGROUND AND AIMS: Arsenic trioxide (As2O3), which used as an effective agent in the treatment of leukaemia and other solid tumors, is largely limited by its toxicity. QT prolongation, torsades de pointes and sudden heart death have been implicated in the cardiotoxicity of As2O3. The present study...

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Bibliographic Details
Main Authors: Xiao-Yan Zhao, Shen Yang, You-Ran Chen, Pei-Chun Li, Meng-Meng Dou, Jie Zhang
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4047048?pdf=render