Small-molecule targeting of MUSASHI RNA-binding activity in acute myeloid leukemia
The RNA binding protein MUSASHI-2 (MSI2) is a potential therapeutic target for acute myeloid leukemia. Here the authors identify a small molecule inhibitor of MSI2 and characterize its effects in a murine leukemia model.
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Nature Publishing Group
2019-06-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-019-10523-3 |
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doaj-0841d30974ee49439a137cb5c41e499b |
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Article |
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DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Gerard Minuesa Steven K. Albanese Wei Xie Yaniv Kazansky Daniel Worroll Arthur Chow Alexandra Schurer Sun-Mi Park Christina Z. Rotsides James Taggart Andrea Rizzi Levi N. Naden Timothy Chou Saroj Gourkanti Daniel Cappel Maria C. Passarelli Lauren Fairchild Carolina Adura J. Fraser Glickman Jessica Schulman Christopher Famulare Minal Patel Joseph K. Eibl Gregory M. Ross Shibani Bhattacharya Derek S. Tan Christina S. Leslie Thijs Beuming Dinshaw J. Patel Yehuda Goldgur John D. Chodera Michael G. Kharas |
| spellingShingle |
Gerard Minuesa Steven K. Albanese Wei Xie Yaniv Kazansky Daniel Worroll Arthur Chow Alexandra Schurer Sun-Mi Park Christina Z. Rotsides James Taggart Andrea Rizzi Levi N. Naden Timothy Chou Saroj Gourkanti Daniel Cappel Maria C. Passarelli Lauren Fairchild Carolina Adura J. Fraser Glickman Jessica Schulman Christopher Famulare Minal Patel Joseph K. Eibl Gregory M. Ross Shibani Bhattacharya Derek S. Tan Christina S. Leslie Thijs Beuming Dinshaw J. Patel Yehuda Goldgur John D. Chodera Michael G. Kharas Small-molecule targeting of MUSASHI RNA-binding activity in acute myeloid leukemia Nature Communications |
| author_facet |
Gerard Minuesa Steven K. Albanese Wei Xie Yaniv Kazansky Daniel Worroll Arthur Chow Alexandra Schurer Sun-Mi Park Christina Z. Rotsides James Taggart Andrea Rizzi Levi N. Naden Timothy Chou Saroj Gourkanti Daniel Cappel Maria C. Passarelli Lauren Fairchild Carolina Adura J. Fraser Glickman Jessica Schulman Christopher Famulare Minal Patel Joseph K. Eibl Gregory M. Ross Shibani Bhattacharya Derek S. Tan Christina S. Leslie Thijs Beuming Dinshaw J. Patel Yehuda Goldgur John D. Chodera Michael G. Kharas |
| author_sort |
Gerard Minuesa |
| title |
Small-molecule targeting of MUSASHI RNA-binding activity in acute myeloid leukemia |
| title_short |
Small-molecule targeting of MUSASHI RNA-binding activity in acute myeloid leukemia |
| title_full |
Small-molecule targeting of MUSASHI RNA-binding activity in acute myeloid leukemia |
| title_fullStr |
Small-molecule targeting of MUSASHI RNA-binding activity in acute myeloid leukemia |
| title_full_unstemmed |
Small-molecule targeting of MUSASHI RNA-binding activity in acute myeloid leukemia |
| title_sort |
small-molecule targeting of musashi rna-binding activity in acute myeloid leukemia |
| publisher |
Nature Publishing Group |
| series |
Nature Communications |
| issn |
2041-1723 |
| publishDate |
2019-06-01 |
| description |
The RNA binding protein MUSASHI-2 (MSI2) is a potential therapeutic target for acute myeloid leukemia. Here the authors identify a small molecule inhibitor of MSI2 and characterize its effects in a murine leukemia model. |
| url |
https://doi.org/10.1038/s41467-019-10523-3 |
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1721446375398309888 |
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doaj-0841d30974ee49439a137cb5c41e499b2021-05-11T11:31:34ZengNature Publishing GroupNature Communications2041-17232019-06-0110111510.1038/s41467-019-10523-3Small-molecule targeting of MUSASHI RNA-binding activity in acute myeloid leukemiaGerard Minuesa0Steven K. Albanese1Wei Xie2Yaniv Kazansky3Daniel Worroll4Arthur Chow5Alexandra Schurer6Sun-Mi Park7Christina Z. Rotsides8James Taggart9Andrea Rizzi10Levi N. Naden11Timothy Chou12Saroj Gourkanti13Daniel Cappel14Maria C. Passarelli15Lauren Fairchild16Carolina Adura17J. Fraser Glickman18Jessica Schulman19Christopher Famulare20Minal Patel21Joseph K. Eibl22Gregory M. Ross23Shibani Bhattacharya24Derek S. Tan25Christina S. Leslie26Thijs Beuming27Dinshaw J. Patel28Yehuda Goldgur29John D. Chodera30Michael G. Kharas31Molecular Pharmacology Program, Experimental Therapeutics Center and Center for Stem Cell Biology, Memorial Sloan-Kettering Cancer CenterLouis V. Gerstner Jr. Graduate School of Biomedical Sciences, Memorial Sloan Kettering Cancer CenterStructural Biology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer CenterWeill Cornell Medical College, Tri-Institutional MD-PhD Program, Rockefeller University and Sloan Kettering InstituteDepartment of Pharmacology, Weill Cornell Graduate School of Medical SciencesMolecular Pharmacology Program, Experimental Therapeutics Center and Center for Stem Cell Biology, Memorial Sloan-Kettering Cancer CenterMolecular Pharmacology Program, Experimental Therapeutics Center and Center for Stem Cell Biology, Memorial Sloan-Kettering Cancer CenterMolecular Pharmacology Program, Experimental Therapeutics Center and Center for Stem Cell Biology, Memorial Sloan-Kettering Cancer CenterChemical Biology Program, Sloan Kettering Institute and Tri-Institutional Research Program, Memorial Sloan Kettering Cancer CenterMolecular Pharmacology Program, Experimental Therapeutics Center and Center for Stem Cell Biology, Memorial Sloan-Kettering Cancer CenterComputational and Systems Biology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer CenterComputational and Systems Biology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer CenterMolecular Pharmacology Program, Experimental Therapeutics Center and Center for Stem Cell Biology, Memorial Sloan-Kettering Cancer CenterMolecular Pharmacology Program, Experimental Therapeutics Center and Center for Stem Cell Biology, Memorial Sloan-Kettering Cancer CenterSchrödinger GmbHComputational and Systems Biology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer CenterComputational and Systems Biology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer CenterHigh-Throughput and Spectroscopy Resource Center, The Rockefeller UniversityHigh-Throughput and Spectroscopy Resource Center, The Rockefeller UniversityHematologic Oncology Tissue Bank, Department of Medicine, Memorial Sloan Kettering Cancer CenterCenter for Hematologic Malignancies, Memorial Sloan Kettering Cancer CenterCenter for Hematologic Malignancies, Memorial Sloan Kettering Cancer CenterNorthern Ontario School of MedicineNorthern Ontario School of MedicineNew York Structural Biology Center, NMR GroupChemical Biology Program, Sloan Kettering Institute and Tri-Institutional Research Program, Memorial Sloan Kettering Cancer CenterComputational and Systems Biology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer CenterSchrödinger, Inc.Structural Biology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer CenterStructural Biology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer CenterComputational and Systems Biology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer CenterMolecular Pharmacology Program, Experimental Therapeutics Center and Center for Stem Cell Biology, Memorial Sloan-Kettering Cancer CenterThe RNA binding protein MUSASHI-2 (MSI2) is a potential therapeutic target for acute myeloid leukemia. Here the authors identify a small molecule inhibitor of MSI2 and characterize its effects in a murine leukemia model.https://doi.org/10.1038/s41467-019-10523-3 |