Statins affect the presentation of endothelial chemokines by targeting to multivesicular bodies.

Statins affect the presentation of endothelial chemokines by targeting to multivesicular bodies.

BACKGROUND: In addition to lowering cholesterol, statins are thought to beneficially modulate inflammation. Several chemokines including CXCL1/growth-related oncogene (GRO)-α, CXCL8/interleukin (IL)-8 and CCL2/monocyte chemoattractant protein (MCP)-1 are important in the pathogenesis of atherosclero...

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Main Authors: Johanna Hol, Kari Otterdal, Unni M Breland, Espen Stang, Turid M Pedersen, Kathrine Hagelsteen, Trine Ranheim, Monika Kasprzycka, Bente Halvorsen, Guttorm Haraldsen, Pål Aukrust
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3398041?pdf=render

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http://europepmc.org/articles/PMC3398041?pdf=render

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