p62-Keap1-NRF2-ARE Pathway: A Contentious Player for Selective Targeting of Autophagy, Oxidative Stress and Mitochondrial Dysfunction in Prion Diseases

p62-Keap1-NRF2-ARE Pathway: A Contentious Player for Selective Targeting of Autophagy, Oxidative Stress and Mitochondrial Dysfunction in Prion Diseases

Prion diseases are a group of fatal and debilitating neurodegenerative diseases affecting humans and animal species. The conversion of a non-pathogenic normal cellular protein (PrPc) into an abnormal infectious, protease-resistant, pathogenic form prion protein scrapie (PrPSc), is considered the eti...

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Bibliographic Details
Main Authors: Syed Zahid Ali Shah, Deming Zhao, Tariq Hussain, Naveed Sabir, Mazhar Hussain Mangi, Lifeng Yang
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-10-01
Series:Frontiers in Molecular Neuroscience
Subjects:
prion protein scrapie (PrPSc)
extracellular plaques
hydrogen peroxide toxicity
mitochondrial dysfunction
nuclear factor erythroid 2-related factor 2 (NRF2)
Online Access:https://www.frontiersin.org/article/10.3389/fnmol.2018.00310/full

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https://www.frontiersin.org/article/10.3389/fnmol.2018.00310/full

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