Phage-assisted continuous evolution of proteases with altered substrate specificity

Phage-assisted continuous evolution of proteases with altered substrate specificity

Proteases are promising therapeutics to treat diseases such as hemophilia which are due to endogenous protease deficiency. Here the authors use phage-assisted continuous evolution to evolve a variant TEV protease with altered target peptide sequence specificities.

Bibliographic Details
Main Authors: Michael S. Packer, Holly A. Rees, David R. Liu
Format: Article
Language:English
Published: Nature Publishing Group 2017-10-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-017-01055-9
Description
Summary:Proteases are promising therapeutics to treat diseases such as hemophilia which are due to endogenous protease deficiency. Here the authors use phage-assisted continuous evolution to evolve a variant TEV protease with altered target peptide sequence specificities.
ISSN:2041-1723

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