The truncate mutation of Notch2 enhances cell proliferation through activating the NF-κB signal pathway in the diffuse large B-cell lymphomas.

The truncate mutation of Notch2 enhances cell proliferation through activating the NF-κB signal pathway in the diffuse large B-cell lymphomas.

The Notch2 is a critical membrane receptor for B-cell functions, and also displays various biological roles in lymphoma pathogenesis. In this article, we reported that 3 of 69 (4.3%) diffuse large B-cell lymphomas (DLBCLs) exhibited a truncate NOTCH2 mutation at the nucleotide 7605 (G/A) in the cDNA...

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Bibliographic Details
Main Authors: Xinxia Zhang, Yaoyao Shi, Yuanyuan Weng, Qian Lai, Taobo Luo, Jing Zhao, Guoping Ren, Wande Li, Hongyang Pan, Yuehai Ke, Wei Zhang, Qiang He, Qingqing Wang, Ren Zhou
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4196756?pdf=render

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http://europepmc.org/articles/PMC4196756?pdf=render

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