Application of fluorescent-based technology detecting protein-protein interactions to monitor the binding of hepatitis B virus X protein to DNA-damage-binding protein 1

Application of fluorescent-based technology detecting protein-protein interactions to monitor the binding of hepatitis B virus X protein to DNA-damage-binding protein 1

The hepatitis B virus X protein (HBx) and the V protein of paramyxovirus simian virus 5 (SV5-V) interact with DNA damage-binding protein 1 (DDB1), a cellular enzyme involved in DNA repair and cell cycle regulation, to stimulate viral activity. DDB1 has several cellular substrates, and the amino acid...

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Bibliographic Details
Main Authors: Katsumi Omagari, Kaori Asamitsu, Yasuhito Tanaka
Format: Article
Language:English
Published: The Biophysical Society of Japan 2021-04-01
Series:Biophysics and Physicobiology
Subjects:
ubiquitination
drug screening
hepatitis b virus x protein
ddb1-clu4a-associated factor 9
fluoppi
Online Access:https://doi.org/10.2142/biophysico.bppb-v18.008

Internet

https://doi.org/10.2142/biophysico.bppb-v18.008

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