α-Synuclein Up-regulates Monoamine Oxidase A Expression and Activity via Trans-Acting Transcription Factor 1

α-Synuclein Up-regulates Monoamine Oxidase A Expression and Activity via Trans-Acting Transcription Factor 1

Abnormal α-Synuclein (α-SYN) aggregates are the pathological hallmarks of Parkinson’s disease (PD), which may affect dopamine (DA) neuron function and DA metabolism. Monoamine oxidase A (MAOA) is an enzyme located on the outer mitochondrial membrane that catalyzes the oxidative deamination of DA. Bo...

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Bibliographic Details
Main Authors:	Congcong Jia, Cheng Cheng, Tianbai Li, Xi Chen, Yuting Yang, Xinyao Liu, Song Li, Weidong Le
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2021-03-01
Series:	Frontiers in Aging Neuroscience
Subjects:	α-Synuclein MAOA Parkinson’s disease Sp1 dopamine
Online Access:	https://www.frontiersin.org/articles/10.3389/fnagi.2021.653379/full

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