α-Synuclein Up-regulates Monoamine Oxidase A Expression and Activity via Trans-Acting Transcription Factor 1

α-Synuclein Up-regulates Monoamine Oxidase A Expression and Activity via Trans-Acting Transcription Factor 1

Abnormal α-Synuclein (α-SYN) aggregates are the pathological hallmarks of Parkinson’s disease (PD), which may affect dopamine (DA) neuron function and DA metabolism. Monoamine oxidase A (MAOA) is an enzyme located on the outer mitochondrial membrane that catalyzes the oxidative deamination of DA. Bo...

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Bibliographic Details
Main Authors: Congcong Jia, Cheng Cheng, Tianbai Li, Xi Chen, Yuting Yang, Xinyao Liu, Song Li, Weidong Le
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-03-01
Series:Frontiers in Aging Neuroscience
Subjects:
α-Synuclein
MAOA
Parkinson’s disease
Sp1
dopamine
Online Access:https://www.frontiersin.org/articles/10.3389/fnagi.2021.653379/full

Internet

https://www.frontiersin.org/articles/10.3389/fnagi.2021.653379/full

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