Lingering single-strand breaks trigger Rad51-independent homology-directed repair of collapsed replication forks in the polynucleotide kinase/phosphatase mutant of fission yeast.

Lingering single-strand breaks trigger Rad51-independent homology-directed repair of collapsed replication forks in the polynucleotide kinase/phosphatase mutant of fission yeast.

The DNA repair enzyme polynucleotide kinase/phosphatase (PNKP) protects genome integrity by restoring ligatable 5'-phosphate and 3'-hydroxyl termini at single-strand breaks (SSBs). In humans, PNKP mutations underlie the neurological disease known as MCSZ, but these individuals are not pred...

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Bibliographic Details
Main Authors: Arancha Sanchez, Mariana C Gadaleta, Oliver Limbo, Paul Russell
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2017-09-01
Series:PLoS Genetics
Online Access:http://europepmc.org/articles/PMC5626526?pdf=render

Internet

http://europepmc.org/articles/PMC5626526?pdf=render

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