Discovery and Evaluation of Thiazinoquinones as Anti-Protozoal Agents

Discovery and Evaluation of Thiazinoquinones as Anti-Protozoal Agents

Pure compound screening has identified the dioxothiazino-quinoline-quinone ascidian metabolite ascidiathiazone A (2) to be a moderate growth inhibitor of Trypanosoma brucei rhodesiense (IC50 3.1 μM) and Plasmodium falciparum (K1 dual drug resistant strain) (IC50 3.3 μM) while exhibiting low levels o...

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Bibliographic Details
Main Authors: Marcel Kaiser, Brent R. Copp, A. Norrie Pearce, Shen H. Tan, Cary F. C. Lam
Format: Article
Language:English
Published: MDPI AG 2013-09-01
Series:Marine Drugs
Subjects:
marine natural products
protozoa
malaria
Plasmodium falciparum
Trypanosoma brucei rhodesiense
quinone
dioxothiazine
alkaloid
Online Access:http://www.mdpi.com/1660-3397/11/9/3472

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http://www.mdpi.com/1660-3397/11/9/3472

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