Melatonin Attenuates Sepsis-Induced Small-Intestine Injury by Upregulating SIRT3-Mediated Oxidative-Stress Inhibition, Mitochondrial Protection, and Autophagy Induction

Melatonin Attenuates Sepsis-Induced Small-Intestine Injury by Upregulating SIRT3-Mediated Oxidative-Stress Inhibition, Mitochondrial Protection, and Autophagy Induction

Melatonin reportedly alleviates sepsis-induced multi-organ injury by inducing autophagy and activating class III deacetylase Sirtuin family members (SIRT1–7). However, whether melatonin attenuates small-intestine injury along with the precise underlying mechanism remain to be elucidated. To investig...

Full description

Bibliographic Details
Main Authors: Siqi Xu, Lulan Li, Jie Wu, Sheng An, Haihong Fang, Yunyang Han, Qiaobing Huang, Zhongqing Chen, Zhenhua Zeng
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-03-01
Series:Frontiers in Immunology
Subjects:
melatonin
sepsis
small intestine
SIRT3
mitochondria
autophagy
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.625627/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2021.625627/full

Similar Items