Wild-Type, but Not Mutant N296H, Human Tau Restores Aβ-Mediated Inhibition of LTP in Tau−/− mice
Microtubule associated protein tau (MAPT) is involved in the pathogenesis of Alzheimer's disease and many forms of frontotemporal dementia (FTD). We recently reported that Aβ-mediated inhibition of hippocampal long-term potentiation (LTP) in mice requires tau. Here, we asked whether expression...
Main Authors: | Mariana Vargas-Caballero, Richard Wade-Martins, Franziska Denk, Heike J. Wobst, Emily Arch, Chrysia-Maria Pegasiou, Peter L. Oliver, Olivia A. Shipton, Ole Paulsen |
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Format: | Article |
Language: | English |
Published: |
Frontiers Media S.A.
2017-04-01
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Series: | Frontiers in Neuroscience |
Subjects: | |
Online Access: | http://journal.frontiersin.org/article/10.3389/fnins.2017.00201/full |
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