Wild-Type, but Not Mutant N296H, Human Tau Restores Aβ-Mediated Inhibition of LTP in Tau−/− mice

Wild-Type, but Not Mutant N296H, Human Tau Restores Aβ-Mediated Inhibition of LTP in Tau−/− mice

Microtubule associated protein tau (MAPT) is involved in the pathogenesis of Alzheimer's disease and many forms of frontotemporal dementia (FTD). We recently reported that Aβ-mediated inhibition of hippocampal long-term potentiation (LTP) in mice requires tau. Here, we asked whether expression...

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Bibliographic Details
Main Authors: Mariana Vargas-Caballero, Richard Wade-Martins, Franziska Denk, Heike J. Wobst, Emily Arch, Chrysia-Maria Pegasiou, Peter L. Oliver, Olivia A. Shipton, Ole Paulsen
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-04-01
Series:Frontiers in Neuroscience
Subjects:
Alzheimer's disease
amyloid beta
frontotemporal dementia
tau
MAPT
N296H
Online Access:http://journal.frontiersin.org/article/10.3389/fnins.2017.00201/full

Internet

http://journal.frontiersin.org/article/10.3389/fnins.2017.00201/full

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