Inhibition of arginase modulates T-cell response in the tumor microenvironment of lung carcinoma

Inhibition of arginase modulates T-cell response in the tumor microenvironment of lung carcinoma

Immunotherapy has demonstrated significant activity in a broad range of cancer types, but still the majority of patients receiving it do not maintain durable therapeutic responses. Amino acid metabolism has been proposed to be involved in the regulation of immune response. Here, we investigated in d...

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Bibliographic Details
Main Authors: Anna Sosnowska, Justyna Chlebowska-Tuz, Pawel Matryba, Zofia Pilch, Alan Greig, Artur Wolny, Tomasz M. Grzywa, Zuzanna Rydzynska, Olga Sokolowska, Tomasz P. Rygiel, Marcin Grzybowski, Paulina Stanczak, Roman Blaszczyk, Dominika Nowis, Jakub Golab
Format: Article
Language:English
Published: Taylor & Francis Group 2021-01-01
Series:OncoImmunology
Subjects:
arginase
tumor microenvironment
immunosuppression
arginase inhibitor
immunotherapy
t-cells response
myeloid cells
Online Access:http://dx.doi.org/10.1080/2162402X.2021.1956143

Internet

http://dx.doi.org/10.1080/2162402X.2021.1956143

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